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Risk and returns can vary greatly when it comes to investing. The funds themselves can differ substantially in volatility, and investors might be more or less risk-adverse. Proven returns and a money manager you can trust are critical when selecting a mutual fund that brings safe, steady growth.

The biggest money managers got there for a reason. With a history of growth and more assets under management, they are trusted bets when it comes to long-term performance. For instance, Prudential Investment Management boasts more than 135 years of investment experience, and Goldman Sachs Asset Management employs over 2,000 professional advisors to manage assets.

Credio sought to identify the best-performing mutual funds to invest in with each of the 10 largest investment advisors. These investment companies control the highest portion of U.S. assets under management, totaling over $11.67 trillion. Upon identifying the 10 largest money managers, we compared mutual funds at each company to find the best-performing funds based on 10-year load adjusted returns.

For those looking to invest with one of the top money managers for long-term performance, these are the 10 top-performing funds (ordered by money manager total AUM) to consider investing in.

Prudential Jennison Health Sciences

Current value of $10,000 invested in 2005: $56,455
Ten-Year Annualized Return: 18.90%
Net Assets: $3.91 Billion
Expense Ratio: 1.08%
Share Class: Institutional

Goldman Sachs Small/Mid Cap Growth

Current value of $10,000 invested in 2005: $31,782
Ten-Year Annualized Return: 12.26%
Net Assets: $2.82 Billion
Expense Ratio: 0.93%
Share Class: Institutional

Northern Mid Cap Index

Current value of $10,000 invested in 2005: $24,671
Ten-Year Annualized Return: 9.45%
Net Assets: $1.68 Billion
Expense Ratio: 0.15%
Share Class: No Load

T. Rowe Price Health Sciences

Current value of $10,000 invested in 2005: $58,465
Ten-Year Annualized Return: 19.31%
Net Assets: $15.7 Billion
Expense Ratio: 0.77%
Share Class: No Load

BlackRock Health Sciences

Current value of $10,000 invested in 2005: $44,642
Ten-Year Annualized Return: 16.14%
Net Assets: $6.16 Billion
Expense Ratio: 0.91%
Share Class: Institutional

Fidelity Select Biotechnology Portfolio

Current value of $10,000 invested in 2005: $60,696
Ten-Year Annualized Return: 19.76%
Net Assets: $16.4 Billion
Expense Ratio: 0.74%
Share Class: No Load

JPMorgan Small Cap Equity

Current value of $10,000 invested in 2005: $31,030
Ten-Year Annualized Return: 11.99%
Net Assets: $3.39 Billion
Expense Ratio: 0.79%
Share Class: Retirement

American Funds New Economy

Current value of $10,000 invested in 2005: $27,186
Ten-Year Annualized Return: 10.52%
Net Assets: $15.7 Billion
Expense Ratio: 0.52%
Share Class: Retirement

PIMCO Corporate & Income Opportunities

Current value of $10,000 invested in 2005: $35,749
Ten-Year Annualized Return: 13.59%
Net Assets: $1.02 Billion
Expense Ratio: 0.91%
Share Class:

Vanguard Health Care

Current value of $10,000 invested in 2005: $35,885
Ten-Year Annualized Return: 13.63%
Net Assets: $52.7 Billion
Expense Ratio: 0.29%
Share Class: Other